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We are a developmental biology lab using the mouse inner ear to investigate topics of cellular morphogenesis and polarity. Our efforts are linked by an overarching goal to inderstand the establishment and maintenance of planar cell polarity (PCP) in cells, tissues and neurons. Current projects address outstanding questions in vestibular hair cell development and cochlear innervation.

Recent Publications

The dark kinase STK32A regulates hair cell polarity opposite of EMX2 in the developing mouse inner ear. Jia S, Ratzan EM, Goodrich EJ, Abrar R, Heiland L, Tarchini B, Deans MR. bioRxiv. 2022Nov;2022.11.02.51490.
PMID: |DOI: 10.1242/dev.192849

Planar cell polarity signaling guides cochlear innervation. Deans MR. Developmental Biology. 2022 Jun;486(1-4). Epub 2022 Mar 17.
PMID: 33046506 |DOI: 10.1242/dev.192849

Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle. Ratzan EM, Moon AM, Deans MR. Development. 2020 Nov 19;147(22):dev192849.
PMID: 33046506 |DOI: 10.1242/dev.192849

Frizzled3 and Frizzled6 cooperate with Vangl2 to direct cohclear innvervation by type II spiral ganglion neurons. Ghimire SR, Deans MR. J. Neuroscience. 2019 Oct 9;39(41).
PMID: 31462532 |DOI: 10.1523/JNEUROSCI.1740-19.2019

A non-autonomous function of the core PCP protein Vangl2 directs peripheral axon turning in the developing cochlea. Ghimire SR, Ratzan EM, Deans MR. Development. 2018 June 14; 145(12).
PMID: 29784671 |DOI: 10.1242/dev.159012

MOre Publications

Department of Neurobiology

The Deans Lab

Department of Surgery & division of otolaryngology

People

Recent Publications

Inner Ear Research Group
Spring 2022 Seminar Series

Looking for opportunities to join the team?

Department of Neurobiology

The Deans Lab

Department of Surgery & division of otolaryngology

People

Recent Publications

Inner Ear Research Group Spring 2022 ​Seminar Series

Looking for opportunities to join the team?

Inner Ear Research Group
Spring 2022 Seminar Series