Recent Publications from the Christian Lab

Kim, H-S., Green, Y., Xie, Y. and Christia, J.L. (2021) Trill dampens Nodal signaling through Pellino2- and Traff6-mediated activation of Nedd4l, PNAS, in press   

Christian, J.L. (2021) A tale of two receptors: Bmps recruit two type I receptors but use the kinase activity of only one, PNAS, 118 (19) e2104745118; https://doi.org/10.1073/pnas.2104745118

Kim, H-S., and Christian, J.L. Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos. JoVE, in press.

Kim, H.S., Neugebauer, J.M., McKnite, A., Tilak, A., and Christian, J.L. (2019) BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis, eLife 8:e48872. Recommended as being of special interest by F1000 Prime. https://f1000.com/prime/736688062

Kim, H.S., McKnite, A. and Christian, J.L. (2019) Proteolytic activation of Bmps: Analysis of cleavage in Xenopus oocytes and embryos, In Bone Morphogenic Proteins: Methods and Protocols, M. Rogers (ed), Methods in Molecular Biology, 1891:115-134.

Kim, H.S., McKnite, A., Xie, Y. and Christian, J.L. (2018) Fibronectin type III and intracellular domains of Toll-like receptor 4 interactor with leucine-rich repeats (Tril) are required for developmental signaling. MBoC, 29:523-531.

Christian, J.L. and Heldin, C-H. (2017) The TGFß superfamily in Lisbon: navigating through development and disease. Development, 144:4476-4480

Huang, W-C, Ferris, E., Cheng, T., Hörndli, C., Gleason, K., Tamminga, C., Wagner, J., Boucher, K., Christian, J.L. and Gregg, C. (2017) Diverse Non-Genetic Allele Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain, Neuron, 93(5):1094-1109

Green, Y.S., Mimoto, M.S., Kwon, S., Xi, Y. and Christian, J.L. (2016) Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos, Development, 143:4016-4026.

Green, Y.S., Kwon, S., and Christian, J.L. (2016) Expression pattern of bcar3, a downstream target of GATA2, and its binding partner, p130cas, during Xenopus development, Gene Exp. Patterns, 20:55-62.

Mimoto, M.S., Kwon, S., Green, Y.S., Goldman, D., and Christian, J.L. (2015) GATA2 regulates Wnt signaling to promote primitive red blood cell fate, Dev. Biol., 407:1-11.

Neugebauer J.M., Kwon, S., Kim, H.S., Donley, N., Tilak, A., Sopory, S., and Christian, J.L. (2015) The prodomain of BMP4 is necessary and sufficient to generate BMP4/7 heterodimers with enhanced in vivo bioactivity, PNAS, 112(18):E2307-2316.

Tilak, A., Nelsen, S., Kim, H.S., Donley, N. McKnite, A., Lee, H. and Christian, J. (2014) Simultaneous rather than ordered cleavage of the BMP4 prodomain leads to ligand loss in mice, Development, 141: 3062-3071.


Full list of publications:
https://www.ncbi.nlm.nih.gov/myncbi/jan.christian.1/bibliography/public/