H. Joseph Yost, Ph.D.

Professor of Neurobiology and Anatomy

Adjunct Professor of Pediatrics

Director, Center for Children

B.S., 1980, Creighton University; Ph.D., 1987, Postdoctoral Research Associate, 1987-1988, University of Chicago; Postdoctoral Research Fellow, 1988-1991, University of California, Berkely; Adminstration for Physician Executives Certificate, 2002, University of Utah.

Email: joseph.yost@genetics.utah.edu
Office Phone: 801-585-6110

Visit the Yost Lab web site

Research

All animals start life as a single cell, the fertilized egg, which divides into hundreds of different cell types. Our long-term research goal is to understand the genes, molecules and developmental mechanisms that regulate the assignment of different cell identities in functionally appropriate positions in the developing vertebrate embryo. These pathways control normal development, aberrant development and cancer development.

Selected Publications

Search Pubmed for H. Joseph Yost's lab publications

Publications (Only 2004 - Present)

  • J.D. Amack and H.J. Yost (2007) T-box gene spadetail plays an early role in zebrafish left-right patterning by controlling Kupffer’s vesicle organogenesis. (submitted)
  • I-C. Tsai, J.D. Amack, Z-H. Gao, V. Band, H.J. Yost and D.M. Virshup (2007) A Wnt-CKIε-Rap1 Pathway Regulates Gastrulation by Modulating E6TP1, a Rap GTPase Activating Protein. Developmental Cell 12, 335-47.
  • W. Luo, A. Peterson, B.A. Garcia, G. Coombs, B. Kofahl, R. Heinrich, J. Shabanowitz, D. F. Hunt, H.J. Yost and D.M. Virshup (2007) Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO, in press.
  • I-C. Tsai, M.Woolf, D.W. Neklason. W.W. Branford, H.J. Yost, R. W. Burt and D.M. Virshup (2007) Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer 120, 1005-12.
  • J.K. Takeuchi, H. Lickert, B.W. Bisgrove, M. Yamamoto, K. Chawengsaksophak, H. Hamada, H.J. Yost, J. Rossant and B.G. Bruneau (2007) Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci 104:846-51.
  • A.B. Cadwallader and H.J. Yost (2007) Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: III. 2-O-sulfotransferase and C5-epimerases. Developmental Dynamics 236, 581-6.
  • L.D. Nadauld, S. Chidester, D. N. Shelton, K. Rai, T. Broadbent, I. T. Sandoval, P. W. Peterson, E. J. Manos, C. M. Ireland, H. J. Yost and D. A. Jones (2006). Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Proc Natl Acad Sci 103: 13409-14.
  • A.B. Cadwallader and H.J. Yost (2006) Combinatorial expression patterns of Heparan Sulfate Sulfotransferases in Zebrafish: II. The 6-O-Sulfotransferase Family. Developmental Dynamics 235, 3432-3437.
  • A.B. Cadwallader and H.J. Yost (2006) Combinatorial expression patterns of Heparan Sulfate Sulfotransferases in Zebrafish: I. The 3-O-Sulfotransferase Family. Developmental Dynamics 235, 3423-3431.
  • M. Sato, H.-J. Tsai and H.J. Yost (2006). Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field. Developmental Biology 289, 12-21.
  • B.W. Bisgrove, B.S. Snarr, A. Emrazian, H. J. Yost (2005) Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Developmental Biology 287(2):274-88.
  • M. Yoshigi, L. M. Hoffman, C.C. Jensen, H.J. Yost, and M.C. Beckerle (2005) Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J. Cell Biol. 171: 209-215.
  • L.D. Nadauld, D.N. Shelton, S. Chidester, H.J. Yost, and Jones, D.A. (2005) The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. J. Biol. Chem. 280, 30490-30495.
  • J.J. Essner, J.D. Amack, M.K. Nyholm, E.B. Harris, and H.J. Yost (2005) Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 132: 1247-60.
  • J.D. Amack and H.J. Yost (2004) The T box transcription factor No Tail in ciliated cells controls zebrafish left-right asymmetry. Current Biology 14, 685-90.

Reviews (Only 2000 - Present)

  • B.W. Bisgrove and H.J. Yost (2006). The roles of cilia in developmental disorders and disease. Development 133, 4131-43.
  • W.W. Branford and H.J. Yost (2004) Nodal signaling: Cryptic Lefty mechanism of antagonism decoded. Current Biology 14: 341-3.
  • H.J. Yost (2003) Left-right asymmetry: nodal cilia make and catch a wave.
    Current Biology 13, 808-809
  • Kramer, K.L., and H.J. Yost (2003). Heparan sulfate core proteins in cell-cell signaling. Annual Review of Genetics 37, 461-84.
  • K.L. Kramer and H. J. Yost (2003) Cardiac Left-Right Development: Are the early steps conserved? Cold Spring Harbor Symposium on Quantitative Biology 149, 37-43.
  • B.W. Bisgrove, S.H. Morelli, H.J. Yost (2003). Genetics of Human Laterality disorders: Insights from vertebrate model systems. Annual Review Genomics and Human Genetics. April 15, 1-32.
  • H.J. Yost (2003) Halpern Explores Asymmetry Using Zebrafish as Model Organism. American Association of Anatomists 12 (2), 12-13.
  • S.M. Prescott, H.J. Yost (2002). The COXes of Danio: from mechanistic model to experimental therapeutics. Proc. National Academy Science 99, 9084-6.
  • B.W. Bisgrove and H.J. Yost (2001) Classification of left-right patterning defects in zebrafish, mice and humans. American Journal of Medical Genetics 101, 315-323.
  • H.J. Yost (2001). Establishment of left-right asymmetry. International Review of Cytology 203, 357-381.
  • H.J. Yost (2000). Specification of cardiac mesenchyme and heart morphogenesis in vitro. Methods in Molecular Biology 136, 35-39.
  • J.L. Lohr and H.J. Yost (2000). Vertebrate model systems in the study of early heart development: Xenopus and zebrafish. American Journal of Medical Genetics 97, 248-257.
  • M.K. Wagner and H.J. Yost (2000). Left-right development: the roles of nodal cilia. Current Biology, 10:149-151.

Textbooks and Chapters

  • J.D. Amack and H.J. Yost (2007). Establishing cardiac left-right asymmetry. In "Heart Development and Regeneration" (R. P. Harvey and N. Rosenthal, eds). Academic Press, San Diego, in preparation.
  • J. Neugebauer and H.J. Yost (2007) Left-Right Axis Determination. Cardiovascular Development, (Rolf Bodmer, ed) Academic Press, in preparation.
  • H.J. Yost (2005) Microenviroment Provides Left-Right Instructions to Migrating Precardiac Mesoderm. In Cardiovascular Development and Congenital Malformations : Molecular and Genetic Mechanisms (Michael Artman, D Woodrow Benson, Deepak Srivastava and Makoto Nakazawa, eds.) Blackwell Publishing, p 3 – 5.
  • M. Sato, H.J.Yost (2005) Neural Crest Cells Contribute to Heart Formation and Cardiomyogenesis in Zebrafish. In Cardiovascular Development and Congenital Malformations : Molecular and Genetic Mechanisms (Michael Artman, D Woodrow Benson, Deepak Srivastava and Makoto Nakazawa, eds.) Blackwell Publishing, p 150 - 152.
  • N. Hu, H. J. Yost, L. F. Barker, E.B. Clark (2005) Spatial Correlation of Conduction Tissue in the Ventricular Trabeculae in Developing Zebrafish. In Cardiovascular Development and Congenital Malformations : Molecular and Genetic Mechanisms (Michael Artman, D Woodrow Benson, Deepak Srivastava and Makoto Nakazawa, eds.) Blackwell Publishing, p 95 - 97.
  • A. Tran, M. Sato, H.J. Yost (2003) Morphological Analysis of Cardiac Defects in Neural Crest Deficient Zebrafish Embryos. Proceedings NCUR 2003. Univ. of North Carolina, Asheville, NC. Volume 3, 73.
  • A.F. Ramsdell and H.J. Yost (2001). Cardiac looping and the left-right axis: integrating morphological, molecular and genetic analyses of vertebrate left-right development. In Development of the Cardiovascular System, Volume 1 (R. J. Tomanek and R. Runyon, eds.) JAI Press, Greenwich, CT.
  • J.M. Opitz, H.J. Yost and E.B. Clark (2000). Syndromes, developmental fields and human congenital cardiovascular malformations. In "Etiology & Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology" (E.B. Clark, M. Nakazawa, A. Takao, eds.) Futura, N.Y., p 311 - 320.
  • H.J. Yost (2000). Axes, situs and the vertebrate body plan. In "Etiology & Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology" (E.B. Clark, M. Nakazawa, A. Takao, eds.) Futura, N.Y., p 3 - 10.
  • H.J. Yost (1998). Establishing cardiac left-right asymmetry. In "Heart Development" (R. P. Harvey and N. Rosenthal, eds). Academic Press, San Diego. p 373-389.
  • H.J. Yost (1995). Breaking Symmetry: Left-Right Cardiac Development in Xenopus laevis. in "Fourth International Symposium on Etiology & Morphogenesis of Congenital Heart Disease - Developmental Mechanisms" (M. M. Markwald, E. B. Clark, A. Takao, eds.) Futura, N.Y., p 505-511.
  • H.J. Yost (1991). Development of the left-right axis in amphibians. In "Biological Asymmetries and Handedness" (eds. G. Bock & J. Marsh). Ciba Foundation Symposium 162, p 165-181. J. Wiley, New York.
  • H.J. Yost, R.B. Petersen and S. Lindquist (1990). Posttranscriptional regulation of heat shock protein synthesis in Drosophila. In "Stress Proteins in Biology and Medicine" (R. I. Morimoto, A. Tissieres, and C. Georgopoulos, Eds.). Cold Spring Laboratory Press, p. 379-409.