H. Joseph Yost, Ph.D.

Professor of Neurobiology and Anatomy

Adjunct Professor of Pediatrics

B.S., 1980, Creighton University; Ph.D., 1987, Postdoctoral Research Associate, 1987-1988, University of Chicago; Postdoctoral Research Fellow, 1988-1991, University of California, Berkely; Adminstration for Physician Executives Certificate, 2002, University of Utah.

Email: joseph.yost@genetics.utah.edu
Office Phone: 801-585-6110

Visit the Yost Lab web site


All animals start life as a single cell, the fertilized egg, which divides into hundreds of different cell types. Our long-term research goal is to understand the genes, molecules and developmental mechanisms that regulate the assignment of different cell identities in functionally appropriate positions in the developing vertebrate embryo. These pathways control normal development, aberrant development and cancer development.

Selected Publications

Search PubMed for H. Joseph Yost's Lab Publications

Publications (Only 2004 - Present)

J.M. Parant, S.A. George, J.A. Holden, and H.J. Yost (2010) Genetic Modeling of Li-Fraumeni Syndrome in zebrafish. Disease Models and Mechanisms 3:45-56.

J.M. Parant, S.A. George, R. Pryor, C.T. Wittwer, and H.J. Yost (2009) A rapid and efficient method of genotyping zebrafish mutants. Developmental Dynamics 238:3168-74.

J.M. Neugebauer, J.D. Amack, A.G. Peterson, B.W. Bisgrove, H.J. Yost (2009) FGF signaling during embryo development regulates cilia length in diverse epithelia. Nature 458:651-4

C.B. Arrington and H.J. Yost (2009) Extraembryonic Syndecan-2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development 136, 3143-52.

X. Wang and H.J. Yost (2008) Initiation and Propagation of Posterior to Anterior (PA) Waves in Zebrafish Left-Right Development. Developmental Dynamics, 237, 3640-7.

J.D. Wythe, M.J. Jurynec, L.D. Urness, C.A. Jones, M. Sato, I.L. Jones, A. Werdich, H.J. Yost, D.J. Milan, D.J. Grunwald, C.A. MacRae and D.Y. Li (2010) HADP1, a Novel Pleckstrin Homology Domain Protein, is Required for Cardiac Contractility in Zebrafish, submitted.

M.A. Wolman, V.K. Sittaramane, J.J. Essner, H.J. Yost, A. Chandrasekhar and M.C. Halloran (2008) Transient axonal glycoprotein-a (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo.  Neural Development 2008 Feb 20;3:6.  PMID 18289389

K.M. Kwan, E. Fujimoto, C. Grabher, B.D. Mangum, M.E. Hardy, D.S. Campbell, J.M. Parant, H.J. Yost, J.P. Kanki, C.B. Chien (2007) The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs. Developmental Dynamics 236, 3088-3099. PMID 17937395

J.D. Amack, X. Wang and H.J. Yost (2007) Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer’s Vesicle in zebrafish. Developmental Biology 310, 196-210. PMID 17765888

W. Luo, A. Peterson, B.A. Garcia, G. Coombs, B. Kofahl, R. Heinrich, J. Shabanowitz, D. F. Hunt, H.J. Yost and D.M. Virshup (2007) Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO 26, 1511-21. PMID 17318175

I-C. Tsai, J.D. Amack, Z-H. Gao, V. Band, H.J. Yost and D.M. Virshup (2007) A Wnt-CKIε-Rap1 Pathway Regulates Gastrulation by Modulating E6TP1, a Rap GTPase Activating Protein. Developmental Cell 12, 335-47. PMID 17336901

I-C. Tsai, M.Woolf, D.W. Neklason. W.W. Branford, H.J. Yost, R. W. Burt and D.M. Virshup (2007) Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer 120, 1005-12. PMID 17131344

A.B. Cadwallader and H.J. Yost (2007) Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: III. 2-O-sulfotransferase and C5-epimerases. Developmental Dynamics 236, 581-6. PMID 17198182

J.K. Takeuchi, H. Lickert, B.W. Bisgrove, X. Sun, M. Yamamoto, K. Chawengsaksophak, H. Hamada, H.J. Yost, J. Rossant and B.G. Bruneau (2007) Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.  Proc Natl Acad Sci 104:846-51. PMID 17210915

A.B. Cadwallader and H.J. Yost (2006) Combinatorial expression patterns of Heparan Sulfate Sulfotransferases in Zebrafish:  II. The 6-O-Sulfotransferase Family. Developmental Dynamics 235, 3432-3437. PMID 17075883

A.B. Cadwallader and H.J. Yost (2006) Combinatorial expression patterns of Heparan Sulfate Sulfotransferases in Zebrafish:  I. The 3-O-Sulfotransferase Family. Developmental Dynamics 235, 3423-3431. PMID 17075882

M. Sato, H.-J. Tsai and H.J. Yost (2006). Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field. Developmental Biology 289, 12-21. PMID 16860789

L.D. Nadauld, S. Chidester, D. N. Shelton, K. Rai, T. Broadbent, I. T. Sandoval, P. W. Peterson, E. J. Manos, C. M. Ireland, H. J. Yost and D. A. Jones (2006). Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.Proc Natl Acad Sci 103: 13409-14. PMID 16938888

B.W. Bisgrove, B.S. Snarr, A. Emrazian, H. J. Yost (2005) Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Developmental Biology 287(2):274-88.  PMID 16216239

M. Yoshigi, L. M. Hoffman, C.C. Jensen, H.J. Yost, and M.C. Beckerle (2005) Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J. Cell Biol. 171: 209-215. PMID16247023

L.D. Nadauld, D.N. Shelton, S. Chidester, H.J. Yost, and Jones, D.A. (2005) The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. J. Biol. Chem. 280, 30490-30495. PMID 15967793

J.J. Essner, J.D. Amack, M.K. Nyholm, E.B. Harris, and H.J. Yost (2005) Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 132: 1247-60. PMID 15716348

L.D. Nadauld, I.T. Sandoval, S. Chidester, H.J. Yost, and D.A. Jones (2004) Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.  J Biol Chem 279, 51581-9. PMID 15358764

J.D. Amack and H.J. Yost (2004) The T box transcription factor No Tail in ciliated cells controls zebrafish left-right asymmetry. Current Biology 14, 685-90. PMID 15084283

Y. Chen, E. Mironova, L. Whitaker, L. Edwards, H.J. Yost, and A. Ramsdell (2004). ALK4 functions as a receptor for multiple TGFb-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus. Development Biology 268, 280-94. PMID 15063168

W. Swiatek, I.C. Tsai, L. Klimowski, A. Pepler, J. Barnette, H.J. Yost, and D.M. Virshup (2004). Regulation of casein kinase I epsilon activity by Wnt signaling. J Biol Chem. 279, 13011-7. PMID 14722104

P. Liang, C.A. Jones, B.W. Bisgrove, L. Song, S.T. Glenn, H.J. Yost, K.W. Gross (2004) Genomic Characterization and expression analysis of the first nonmammalian rennin genes from zebrafish and pufferfish. Physiology Genomics 16, 314-22. PMID 14645735

Reviews (Only 2000 - Present)

H.J. Yost (2010). Left-Right Patterning. Annual Review of Genetics 43, in preparation.

H.J. Yost (2010). Proteoglycans, Glycobiology and Development. Current Opinions in Genetics and Development, in preparation.

H.J. Yost (2009). Coordinating the development of bilateral symmetry and left-right asymmetry Semin Cell Dev Biol 20:455

B.W. Bisgrove and H.J. Yost (2006). The roles of cilia in developmental disorders and disease. Development 133, 4131-43. PMID 17021045

W.W. Branford and H.J. Yost (2004) Nodal signaling: Cryptic Lefty mechanism of antagonism decoded. Current Biology 14: 341-3. PMID 15120085

H.J. Yost (2003) Left-right asymmetry: nodal cilia make and catch a wave. Current Biology 13, 808-809. PMID 14561422

Kramer, K.L., and H.J. Yost (2003). Heparan sulfate core proteins in cell-cell signaling. Annual Review of Genetics 37, 461-84. PMID 14616070.

B.W. Bisgrove, S.H. Morelli, H.J. Yost (2003). Genetics of Human Laterality disorders: Insights from vertebrate model systems. Annual Review Genomics and Human Genetics. April 15, 1-32. PMID 12730129

H.J. Yost (2003) Halpern Explores Asymmetry Using Zebrafish as Model Organism. American Association of Anatomists 12 (2), 12-13.

S.M. Prescott, H.J. Yost (2002). The COXes of Danio: from mechanistic model to experimental therapeutics. Proc. National Academy Science 99, 9084-6. PMID 12093922

K.L. Kramer and H. J. Yost (2002) Cardiac Left-Right Development: Are the early steps conserved? Cold Spring Harbor Symposium on Quantitative Biology 149, 37-43. PMID 12858521

B.W. Bisgrove and H.J. Yost (2001) Classification of left-right patterning defects in zebrafish, mice and humans. American Journal of Medical Genetics 101, 315-323. PMID 11471153

H.J. Yost (2001). Establishment of left-right asymmetry. International Review of Cytology 203, 357-381. PMID 11131521

M.K. Wagner and H.J. Yost (2000).  Left-right development: the roles of nodal cilia. Current Biology, 10:149-151. PMID 10704402

J.L. Lohr and H.J. Yost (2000). Vertebrate model systems in the study of early heart development: Xenopus and zebrafish. American Journal of Medical Genetics 97, 248-257. PMID 11376436

H.J. Yost (2000).  Specification of cardiac mesenchyme and heart morphogenesis in vitro.  Methods in Molecular Biology 136, 35-39. PMID 10840695

Textbooks and Chapters

J.D. Amack and H.J. Yost (2008).  Establishing cardiac left-right asymmetry.  In "Heart Development and Regeneration" (R. P. Harvey and N. Rosenthal, eds). Academic Press, San Diego, in press.

J.M. Neugebauer and H.J. Yost (2007) Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in Left-Right Development. Cardiovascular Development (Rolf Bodmer, ed). Academic Press, in press.

H.J. Yost (2005) Microenviroment Provides Left-Right Instructions to Migrating Precardiac Mesoderm. In Cardiovascular Development and Congenital Malformations : Molecular and Genetic Mechanisms (Michael Artman, D Woodrow Benson, Deepak Srivastava and Makoto Nakazawa, eds.) Blackwell Publishing, p 3 – 5.

M. Sato, H.J.Yost (2005) Neural Crest Cells Contribute to Heart Formation and Cardiomyogenesis in Zebrafish. In Cardiovascular Development and Congenital Malformations : Molecular and Genetic Mechanisms (Michael Artman, D Woodrow Benson, Deepak Srivastava and Makoto Nakazawa, eds.) Blackwell Publishing, p 150 - 152.

N. Hu, H. J. Yost, L. F. Barker, E.B. Clark (2005) Spatial Correlation of Conduction Tissue in the Ventricular Trabeculae in Developing Zebrafish. In Cardiovascular Development and Congenital Malformations : Molecular and Genetic Mechanisms (Michael Artman, D Woodrow Benson, Deepak Srivastava and Makoto Nakazawa, eds.) Blackwell Publishing, p 95 - 97.

A. Tran, M. Sato, H.J. Yost (2003) Morphological Analysis of Cardiac Defects in Neural Crest Deficient Zebrafish Embryos. Proceedings NCUR 2003. Univ. of North Carolina, Asheville, NC. Volume 3, 73.

A.F. Ramsdell and H.J. Yost (2001). Cardiac looping and the left-right axis: integrating morphological, molecular and genetic analyses of vertebrate left-right development. In Development of the Cardiovascular System, Volume 1 (R. J. Tomanek and R. Runyon, eds.) JAI Press, Greenwich, CT.

J.M. Opitz, H.J. Yost and E.B. Clark (2000). Syndromes, developmental fields and human congenital cardiovascular malformations. In "Etiology & Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology" (E.B. Clark, M. Nakazawa, A. Takao, eds.) Futura, N.Y., p 311 - 320.

H.J. Yost (2000). Axes, situs and the vertebrate body plan. In "Etiology & Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology" (E.B. Clark, M. Nakazawa, A. Takao, eds.) Futura, N.Y., p 3 - 10.

H.J. Yost (1998).  Establishing cardiac left-right asymmetry.  In "Heart Development" (R. P. Harvey and N. Rosenthal, eds). Academic Press, San Diego. p 373-389.

H.J. Yost (1995).  Breaking Symmetry:  Left-Right Cardiac Development in Xenopus laevis.  in "Fourth International Symposium on Etiology & Morphogenesis of Congenital Heart Disease - Developmental Mechanisms" (M. M. Markwald, E. B. Clark, A. Takao, eds.) Futura, N.Y., p 505-511.

H.J. Yost (1991).  Development of the left-right axis in amphibians. In "Biological Asymmetries and Handedness"  (eds. G. Bock & J. Marsh). Ciba Foundation Symposium 162, p 165-181. J. Wiley, New York. PMID 1802642

H.J. Yost, R.B. Petersen and S. Lindquist (1990).  Posttranscriptional regulation of heat shock protein synthesis in Drosophila.  In  "Stress Proteins in Biology and Medicine" (R. I. Morimoto, A. Tissieres, and C. Georgopoulos, Eds.).  Cold Spring Laboratory Press, p. 379-409.