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Research

The research in my laboratory is focused on neuronal development, using chick hindlimb as a model system. Our overall goals are to understand how neurons acquire their identity and to elucidate the molecular nature of the cues that guide sensory and motor axons to their targets during embryonic development. For example, we are investigating the role of Eph receptor tyrosine kinases and their ligands, ephrins, in patterning axon outgrowth in the limb. Another project centers on the role of retinoid signaling in the governing the timing and pattern of axon growth into the limb. We are also investigating the developmental regulation of ETS transcription factors in sensory and motor neurons. My laboratory employs a variety of techniques including embryonic surgery, cell culture, immunohistochemistry and molecular approaches to address these questions.

Selected Publications

Search PubMed for Sheryl Scott's Lab Publications

• Wang, GY and S. A. Scott (2008) Retinoid signaling is involved in governing the waiting period for axons in chick hindlimb. Dev. Biol. 321, 216-226.
• Guan, W., GY Wang, S. A. Scott, and M. L. Condic (2008) Shh influences cell number and the distribution of neuronal subtypes in dorsal root ganglia. Dev. Biol.  314, 317-328.
• Wu, Y., GY Wang, S. A. Scott, and M. R. Capecchi  (2008) Hoxc10 and d10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development. 135, 171-182.
• Wang, GY and S. A. Scott (2007) Onset of ETS expression is not accelerated by premature exposure to signals from limb mesenchyme.  Dev. Dyn. 236, 2109-2117.
• Muñoz, L. M., A. Zayachkivsky, R. B. Kunz, J. M. E. Hunt, GY. Wang, and S. A. Scott (2005) Ephrin-A5 inhibits growth of embryonic sensory neurons. Dev. Biol. 283, 397-408.
• Wang, GY and S. A. Scott (2004) An early broad competence of motoneurons to express ER81 is later sculpted by the periphery. J. Neurosci. 24, 9789-9798.
• Wang, GY and S. A. Scott (2002) Development of "normal" dermatomes and somatotopic maps by "abnormal" populations of cutaneous neurons. Dev. Biol. 251, 424-433.
• Winseck, A. K., J. Caldero, D. Ciutat, D. Prevette, S. A. Scott, GY Wang, J. E. Esquerda, R. W. J. Oppenheim. (2002) In vivo analysis of Schwann cell programmed cell death in the embryonic chick: regulation by axons and glial growth factor. J. Neurosci. 22, 4509-21
• Cahoon-Metzger, S. M, GY. Wang and S. A. Scott (2001) Contribution of BDNF-mediated inhibition in patterning avian skin innervation. Dev. Biol. 232, 246-54
• Wang, GY. and S. A. Scott (2000) The "waiting period" of sensory and motor axons in early chick hindlimb: Its role in axon pathfinding and neuronal maturation. J. Neurosci. 20, 5358-5366.