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Research

Experimentally defining the genetics that shape the brain- and ultimately the behaviors it controls, such as those leading to the complex outcomes of addiction and age-related pathologies -is a challenging but promising endeavor. In this context, we use a mouse genetic approach to explore the interactions between nicotine addiction, inflammation and age-related degenerative disorders. Like humans, mice of different genetic background also exhibit remarkably different physiological mechanism(s) leading to nicotine dependence, regulation of inflammatory processes, and susceptibility to a variety of maladies experienced with age. Because we believe these processes are interactive, the mouse model appears to hold promise as a powerful tool for understanding how genetics and behavioral measures combine to individualize the physiological responses to nicotine as we age.

Selected Publications

Search Pubmed for Scott Roger's lab publications

Representative Papers

• Gahring, LC, and Rogers SW. 2008. Nicotinic Acetylcholine Receptor Expression in the Hippocampus of 27 Mouse Strains Reveals Novel Inhibitory Circuitry. Hippocampus, 18(8):737-49.
• Rogers, S.W., Weis JJ, Ma Y, Teuscher C, Gahring LC. 2008. Mouse Chromosome 11 Harbors Genetic Determinants of Hippocampal Strain-Specific Nicotinic Receptor Expression. Hippocampus, 18(8):750-7.
• Gahring, LC, Osborne-Hereford A, Vasquez G and Rogers SW. 2008. TNFalpha enhances nicotinic receptor upregulation via a p38MAPK-dependent pathway. J. Biol. Chem. 283:693-9.
• Osborne-Hereford, A, Vasquez G, Rogers SW and Gahring LC. 2008. Neuronal Nicotinic alpha7 Receptors Modulate Inflammatory Cytokine Production in the Skin Following Ultraviolet Radiation. J. Neuroimmunol. 193:130-9.
• Gahring LC, K Persiyanov, and Rogers SW. 2005. Mouse Strain-specific changes in nicotinic receptor expression with age. Neurobiol. Aging, 6:973-80.
• Gahring LC, K Persiyanov, EL Days and SW Rogers. 2005. Nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase 2 and PPARγ expression and is altered by long-term NS398 administration. J. Neurobiol., 62:453-68.
• Gahring LC, et al.,and SW Rogers. 2005. Pro-Inflammatory Cytokines Modify Neuronal Nicotinic Acetylcholine Receptor Assembly. J. Neuroimmunology, 166:88-101.
• Gahring LC, EL Meyer, and SW Rogers. Nicotine-induced neuroprotection against NMDA or beta-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines. J. Neurochem, 87: 1125-1136, 2003.

Recent Reviews

• Rogers, SW, Baker T, and Gould TJ. 2008. Chapter 3: Mouse Models and the Genetics of Nicotine Addiction. In: NCI Monograph 22, Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. U.S. Dept. Health and Human Services; In press.
• Albuquerque, EX, Pereira EFR, Alkondon M, and Rogers SW. 2008. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiological Reviews, in press.
• Gahring LC, and Rogers SW. Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. AAPS J. 2006 Jan 13;7(4):E885-94.

Hobby Studies on Dinosaur Neurobiology

• Rogers, S.W. (2005) Reconstructing the behaviors of extinct species: An excursion into comparative paleoneurology. Amer. J Med. Gen., 134:349-56.
• Rogers, SW. 1999. Allosaurus, crocodiles, and birds: evolutionary clues from spiral computed tomography of an endocast. Anat Rec. 15;257(5):162-73.
• Rogers, S.W. Exploring Dinosaur NeuroPaleobiology: Computed Tomography Scanning and Analysis of an Allosaurus fragilis Endocast. Neuron 21:673-679, 1998.

Scientific Advisor and Contributor to 2 BBC/Discovery Channel Science Productions

• Walking with Dinosaurs: Allosaurus (2001)
• The Truth About Killer Dinosaurs (2006)