Maureen Condic, Ph.D.
Associate Professor of Neurobiology and Anatomy
Ph.D., University of California, Berkeley; Postdoctoral Fellow, University of California, Berkeley and University of Minnesota.
Office Phone: 801-585-3482
Dr. Condic is interested in the control of neurite outgrowth and axon guidance. Embryonic neurons are unusual in that they are able to extend neurites quite efficiently in extracellular environments that do not support the migration of other motile cell types.
Recent work in the laboratory has shown that embryonic sensory neurons are able to compensate for inhibitory or weakly growth-promoting substrata by adjusting their expression of receptors for growth-promoting matrix molecules (receptors of the integrin class). Cell-surface integrin levels appear to be modulated either through a posttranslational mechanism of targeted endocytosis or through activation of a receptor-based second messenger system. Regulated integrin expression in response to the extracellular environment may be required for neurons (and possibly for other invasive cell types) to migrate into diverse tissues.
We are currently investigating the contribution of integrin regulation to the development and migration of both sensory neurons and their immediate embryonic precursors, the neural crest. An exciting suggestion from this work is that the regenerative failure of adult CNS neurons may be in part due to changes in integrin expression associated with the maturation of neurons to an adult phenotype. Recent work from our laboratory has demonstrated that the regeneration of adult neurons in culture can be greatly improved by transgenic integrin expression. We are currently expanding these findings to more sophisticated in vitro and whole animal models of adult regeneration.
- Strachan, L. R. and Condic, M.L. (2008). (Epub Nov 1, 2007). Neural crest motility on fibronectin is regulated by integrin activation. Exp. Cell Res. 314 (3); 441-452.
- Condic, M.L. (2008). Alternative sources of pluripotent stem cells; altered nuclear transfer. Cell Proliferation, 41 (Suppl. 1), 7-19.
- Guan, W. Wang, G., Scott, S.A. and Condic, M.L. (2008). (Epub Dec 4, 2007). Shh regulates cell number and neuronal identity in dorsal root ganglia. Dev. Biol. 15;314(2):317-28.
- Lemons, M. L. and Condic, M.L. (2008). (Epub 14 Jun, 2007). Integrin signaling is integral to regeneration. Experimental Neurology. 209(2):343-52.
- Rao, M. and Condic M.L. (2008). Alternative sources of pluripotent stem cells: Scientific solutions to an ethical dilemma. Stem Cells and Development. 17(1): 1-10.
- Condic, M.L. and Rao, M. (2008). Regulatory issues for personalized pluripotent cells. Stem Cells. (Jul 31. [Epub ahead of print]).
- Condic, M.L. (2008). Getting Stem Cells Right. First Things. 180: 10-12.
- Berg, T.V. and Condic, M.L. (2008). Emerging Biotechnologies, the Defense of Embryonic Human Life, and Altered Nuclear Transfer. Linacre Quarterly. 75(4): 269-291.
- Condic, M.L. (2007). The beginning of life: a perspective from science. DeVos Medical Ethics Colloquy. Van Andel Press. Grand Rapids, MI.
- Condic, M.L. and Furton, E..J. (2007). Harvesting Embryonic Stem Cells from Deceased Human Embryos. Natl Cathol Bioeth Quart. 7(3):507-525.
- Lemons, M.L. and Condic, M.L. (2006). Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1. Exp. Neurol. 202, 324-335.
- Lemons, M.L., Barua, S. Abanto, M.L., Halfter, W. and Condic, M.L. (2005). Adaptation of sensory neurons to hyalectin and decorin proteoglycans. J. Neuroscience 25, 4964-73.Strachan, L. R. and Condic, M.L. (2004). Mechanisms of substratum-dependent integrin regulation in neural crest. J. Cell Biology167(3):545-54.
- Guan, W. Puthenveedu, M. and Condic, M.L. (2003). Sensory neuron subtypes have unique substratum preference and receptor gene expression prior to target innervation. J. Neurosci. 23, 1781-1791.
- Guan, W. and Condic, M.L. (2003). Characterization of Netrin-1, Neogenin and UNC-5 expression during chick dorsal root ganglion development. Mech. Dev. (Gene expression patterns) 3(3), 367-371.
- Strachan, L. and Condic, M.L. (2003). Neural crest motility and integrin regulation are distinct in cranial and trunk populations. Dev. Biol. 259, 288-302.