2B458 School of Medicine 2nd Floor - (801) 581-6157
Schoenwolf office: 2R066 School of medicine 2nd floor - (801) 581-6453
developmental dynamics office: 2r066 school of medicine 2nd floor - (801) 587-9152
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Welcome to the Schoenwolf laboratory home page.
The Schoenwolf laboratory addresses the general question of how intercellular and intracellular signaling results in the generation of pattern during vertebrate embryogenesis. Although we work on a number of diverse organ rudiments and developmental events using multiple experimental organisms, our current work is focused on normal and abnormal development of the inner ear. Our research combines molecular, cellular, embryological, transgenic, imaging, and in vitro and in vivo approaches. This work is relevant for understanding birth defects, cancer, and aging.
Long-term collaborator: Suzanne Mansour, Professor Human Genetics.
|Sho Ohta||Studying the roles of BMP and SHH signaling in dorsoventral patterning of the developing inner ear.|
|Steve Bleyl||Studying the roles of PDGF signaling in normal pulmonary vein development and TAPVR.|
|Courtney Montgomery||Editorial Assistant,
|Susan Chapman||Assistant Professor,
|Christian Paxton||R&D Specialist,
|Junko Nishita||Cardiology Resident,
Tokyo Women's Medical University
|Mariko Sata||Pediatric Resident,
University of Utah
|Mike deCastro||Self Employed,
Salt Lake City, Utah
|Raj Ladher||Group Leader,
Bleyl, S.B, J.L.B. Byrne, S.T. South, D.C. Dries, D.A. Stevenson, A.F. Rope, A.M. Vianna-Morgante, G.C. Schoenwolf, J.D. Kivlin, A. Brothman and J.C. Carey 2007 Brachymesomelic dysplasia with Peters anomaly of the eye results form disruptions of the X chromosome near the SHOX and SOX3 genes. Am. J. Med. Genet., Part A, 143A:2785-2795.
Bleyl, S.B., A. Moshrefi, M. Shaw, Y. Saijoh, G.C. Schoenwolf, L.A. Pennacchio and A.M Slavotinek 2007 Candidate genes for congenital diaphragmatic hernia from animal models: Sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients. Eur. J. Hum. Genet., 15:950-958.
Chapman, S.C., K. Matsumoto, Q. Cai and G.C. Schoenwolf 2007 Specification of germ layer identity in the chick gastrula. BioMed Central Dev. Biol., 7:91-107.
Schoenwolf, G.C. 2008 Atlas of Descriptive Embryology, 7th Edition. Benjamin Cummings, San Francisco. 8-1/2 X 11”; 306 pages; 342 illustrations.
Schoenwolf, G.C., S.B. Bleyl, P.R. Brauer and P.H. Francis-West 2009 Larsen’s Human Embryology. 4th Edition. Churchill Livingstone, Philadelphia. 8 X 10”; 687 pages; 469 illustrations.
Schoenwolf, G.C. 2009 Laboratory Studies of Vertebrate and Invertebrate Embryos. Guide and Atlas of Descriptive and Experimental Development, 9th Edition. Benjamin Cummings, San Francisco. 8-1/2 X 11”; 388 pages; 549 illustrations.
Bleyl, S.B., Y. Saijoh, N.A.M Bax, A.C. Gittenberger-de Groot, L.J. Wisse, S.C. Chapman, J. Hunter, H. Shiratori, H. Hamada, S. Yamada, K. Shiota, S.E. Klewer, M.F. Leppert and G.C. Schoenwolf 2010 Dysregulation of the PDGFA gene causes inflow tract anomalies including TAPVR: Integrating evidence from human genetics and model organisms. Human Mol. Genet., 19:1286-1301.
Paxton, C.N., S.B. Bleyl, S.C. Chapman and G.C. Schoenwolf 2010 Identification of differentially expressed genes in early nner ear development. Gene Exp. Patterns 10:31-43.
Urness, L.D., C.N. Paxton, X. Wang, G.C. Schoenwolf and S.L. Mansour 2010 FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev. Biol., 340:595-604.
Ohta, S., S.L. Mansour and G.C. Schoenwolf 2010 BMP/SMAD signaling regulates initial dorsal-specific regional morphogenesis of the otocyst. Dev. Biol., 347:369-381.
Nishita, J., S. Ohta, S.B. Bleyl and G.C. Schoenwolf 2011 Detection of isoform-specific FGF receptors by whole mount in situ hybridization in chick. Dev. Dyn., 240, 1537-1547.